The CRUCIAL publications

Publications

Here you can find all publications about the project

Mural cell dysfunction contributes to diastolic heart failure by promoting endothelial dysfunction and vessel remodelling

Grootaert MOJ, Pasut A, Raman J, Simmonds SJ, Callewaert B, Col Ü, Dewerchin M, Carmeliet P, Heymans S, Jones EAV. Mural cell dysfunction contributes to diastolic heart failure by promoting endothelial dysfunction and vessel remodelling. Cardiovasc Diabetol. 2025 Feb 7;24(1):62. doi: 10.1186/s12933-025-02623-w. PMID: 39920783; PMCID: PMC11806843.

Safety of ward-based, non-physician-led, cardiac monitor implantation

Procter WTC, Bennett J, Elliott J, Mravljak R, Thornton GD, Aziminia N, Gama F, Nitsche C, Carter Z, Binoy J, Monkhouse C, Earley M, Hunter RJ, Treibel TA. Safety of ward-based, non-physician-led, cardiac monitor implantation. Heart Rhythm. 2024 Jul 4:S1547-5271(24)02874-1. doi: 10.1016/j.hrthm.2024.07.003. Epub ahead of print. PMID: 38971418. (open access)

Left Ventricular Hypertrophy in Aortic Stenosis: Early Cell and Matrix Regression 2 Months Post-Aortic Valve Replacement

Bennett J, Thornton GD, Nitsche C, Gama FF, Aziminia N, Gul U, Shetye A, Kellman P, Davies RH, Moon JC, Treibel TA; Barts Valve and Imaging Group. Circ Cardiovasc Imaging. 2024 Dec;17(12):e017425. doi: 10.1161/CIRCIMAGING.124.017425. Epub 2024 Dec 4. PMID: 39629586; PMCID: PMC11649182.

Heterogeneity and Penumbra of White Matter Hyperintensities in Small Vessel Diseases Determined by Quantitative MRI

Voorter PHM, Stringer MS, van Dinther M, Kerkhofs D, Dewenter A, Blair GW, Thrippleton MJ, Jaime Garcia D, Chappell FM, Janssen E, Kopczak A, Staals J, Ingrisch M, Duering M, Doubal FN, Dichgans M, van Oostenbrugge RJ, Jansen JFA, Wardlaw JM, Backes WH; SVDs@target Consortium. Stroke. 2025 Jan;56(1):128-137. doi: 10.1161/STROKEAHA.124.047910. Epub 2024 Dec 9. PMID: 39648904.

Heart-Brain Connection consortium. Lower cerebral blood flow predicts cognitive decline in patients with vascular cognitive impairment

van Dinther M, Hooghiemstra AM, Bron EE, Versteeg A, Leeuwis AE, Kalay T, Moonen JE, Kuipers S, Backes WH, Jansen JFA, van Osch MJP, Biessels GJ, Staals J, van Oostenbrugge RJ; Heart-Brain Connection consortium. Lower cerebral blood flow predicts cognitive decline in patients with vascular cognitive impairment. Alzheimers Dement. 2024 Jan;20(1):136-144. doi: 10.1002/alz.13408. Epub 2023 Jul 25. PMID: 37491840. (open access)

Blood-Brain Barrier Integrity Decreases With Higher Blood Pressure: A 7T DCE-MRI Study

van den Kerkhof M, de Jong JJA, Voorter PHM, Postma AA, Kroon AA, van Oostenbrugge RJ, Jansen JFA, Backes WH. Blood-Brain Barrier Integrity Decreases With Higher Blood Pressure: A 7T DCE-MRI Study. Hypertension. 2024 Oct;81(10):2162-2172. doi: 10.1161/HYPERTENSIONAHA.123.22617. Epub 2024 Aug 13. PMID: 39136128; PMCID: PMC11404763. (open access)

Myocardial Interstitial Fibrosis in Hypertensive Heart Disease: From Mechanisms to Clinical Management.

González A, López B, Ravassa S, San José G, Latasa I, Butler J, Díez J. Myocardial Interstitial Fibrosis in Hypertensive Heart Disease: From Mechanisms to Clinical Management. Hypertension. 2024 Feb;81(2):218-228. doi: 10.1161/HYPERTENSIONAHA.123.21708. Epub 2023 Dec 12. PMID: 38084597

Circulating biomarkers of myocardial remodelling: current developments and clinical applications

López B, Ravassa S, San José G, Latasa I, Losada-Fuentenebro B, Tapia L, Díez J, Bayés-Genís A, González A. Circulating biomarkers of myocardial remodelling: current developments and clinical applications. Heart. 2024 Sep 16;110(19):1157-1163. doi: 10.1136/heartjnl-2024-323865. PMID: 39117384. (NOT open access)

The neurovascular unit and its correlation with cognitive performance in patients with cerebral small vessel disease: a canonical correlation analysis approach

van Dinther M, Voorter PHM, Zhang E, van Kuijk SMJ, Jansen JFA, van Oostenbrugge RJ, Backes WH, Staals J. The neurovascular unit and its correlation with cognitive performance in patients with cerebral small vessel disease: a canonical correlation analysis approach. Geroscience. 2024 Oct;46(5):5061-5073. doi: 10.1007/s11357-024-01235-8. Epub 2024 Jun 18. PMID: 38888875; PMCID: PMC11335703. (open access)

Diffusion-derived intravoxel-incoherent motion anisotropy relates to CSF and blood flow

Voorter PHM, Jansen JFA, van der Thiel MM, van Dinther M, Postma AA, van Oostenbrugge RJ, Gurney-Champion OJ, Drenthen GS, Backes WH. Diffusion-derived intravoxel-incoherent motion anisotropy relates to CSF and blood flow. Magn Reson Med. 2024 Nov 6. doi: 10.1002/mrm.30294. Epub ahead of print. PMID: 39503237. (open access)

Origin and flow-mediated remodeling of the murine and human extraembryonic circulation systems

Van Schoor K, Bruet E, Jones EAV, Migeotte I. Origin and flow-mediated remodeling of the murine and human extraembryonic circulation systems. Front Physiol. 2024 May 16;15:1395006. doi: 10.3389/fphys.2024.1395006. PMID: 38818524; PMCID: PMC11137303. (open access)

Intravoxel incoherent motion as a surrogate marker of perfused vascular density in rat brain

Callewaert B, Gsell W, Lox M, Backes WH, Jones EAV, Himmelreich U. Intravoxel incoherent motion as a surrogate marker of perfused vascular density in rat brain. NMR Biomed. 2024 Sep;37(9):e5148. doi: 10.1002/nbm.5148. Epub 2024 Mar 31. PMID: 38556903. (NOT open access)

A timeline study on vascular co-morbidity induced cerebral endothelial dysfunction assessed by perfusion MRI

Callewaert B, Gsell W, Lox M, Himmelreich U, Jones EAV. A timeline study on vascular co-morbidity induced cerebral endothelial dysfunction assessed by perfusion MRI. Neurobiol Dis. 2024 Oct 19;202:106709. doi: 10.1016/j.nbd.2024.106709. Epub ahead of print. PMID: 39433136. (open access)

Myocardial Hypoperfusion in Severe Aortic Stenosis Is Reversed Early After Aortic Valve Replacement

Thornton GD, Bennett JB, Nitsche C, Gama F, Aziminia N, Knott K, Davies RH, Moon JC, Kellman P, Treibel TA. Myocardial Hypoperfusion in Severe Aortic Stenosis Is Reversed Early After Aortic Valve Replacement. JACC Cardiovasc Imaging. 2024 Aug;17(8):1006-1008. doi: 10.1016/j.jcmg.2024.03.008. Epub 2024 Apr 24. PMID: 38661608.

Generation of Self-Induced Myocardial Ischemia in Large-Sized Cardiac Spheroids without Alteration of Environmental Conditions Recreates Fibrotic Remodeling and Tissue Stiffening Revealed by Constriction Assays

Paz-Artigas L, González-Lana S, Polo N, Vicente P, Montero-Calle P, Martínez MA, Rábago G, Serra M, Prósper F, Mazo MM, González A, Ochoa I, Ciriza J. Generation of Self-Induced Myocardial Ischemia in Large-Sized Cardiac Spheroids without Alteration of Environmental Conditions Recreates Fibrotic Remodeling and Tissue Stiffening Revealed by Constriction Assays. ACS Biomater Sci Eng. 2024 Feb 12;10(2):987-997. doi: 10.1021/acsbiomaterials.3c01302. Epub 2024 Jan 17. PMID: 38234159.

Lower cerebral blood flow predicts cognitive decline in patients with vascular cognitive impairment. Alzheimers Dement.

Blood-Brain Barrier Disruption and Perivascular Spaces in Small Vessel Disease and Neurodegenerative Diseases: A Review on MRI Methods and Insights

Voorter PHM, van Dinther M, Jansen WJ, Postma AA, Staals J, Jansen JFA, van Oostenbrugge RJ, van der Thiel MM, Backes WH. Blood-Brain Barrier Disruption and Perivascular Spaces in Small Vessel Disease and Neurodegenerative Diseases: A Review on MRI Methods and Insights. J Magn Reson Imaging. 2024 Feb;59(2):397-411. doi: 10.1002/jmri.28989. Epub 2023 Sep 1. PMID: 37658640.

Pericyte loss initiates microvascular dysfunction in the development of diastolic dysfunction

Simmonds SJ, Grootaert MOJ, Cuijpers I, Carai P, Geuens N, Herwig M, Baatsen P, Hamdani N, Luttun A, Heymans S, Jones EAV. Pericyte loss initiates microvascular dysfunction in the development of diastolic dysfunction. Eur Heart J Open. 2023 Dec 9;4(1):oead129. doi: 10.1093/ehjopen/oead129. PMID: 38174347.

Effect of blood pressure-lowering agents on microvascular function in people with small vessel diseases (TREAT-SVDs): a multicentre, open-label, randomised, crossover trial

Kopczak A, Stringer MS, van den Brink H, Kerkhofs D, Blair GW, van Dinther M, Reyes CA, Garcia DJ, Onkenhout L, Wartolowska KA, Thrippleton MJ, Kampaite A, Duering M, Staals J, Lesnik-Oberstein S, Muir KW, Middeke M, Norrving B, Bousser MG, Mansmann U, Rothwell PM, Doubal FN, van Oostenbrugge R, Biessels GJ, Webb AJS, Wardlaw JM, Dichgans M; TREAT-SVDs collaborators. Effect of blood pressure-lowering agents on microvascular function in people with small vessel diseases (TREAT-SVDs): a multicentre, open-label, randomised, crossover trial. Lancet Neurol. 2023 Nov;22(11):991-1004. doi: 10.1016/S1474-4422(23)00293-4. PMID: 37863608. Not open access

Assessment of Microvascular Disease in Heart and Brain by MRI: Application in Heart Failure with Preserved Ejection Fraction and Cerebral Small Vessel Disease

Bennett J, van Dinther M, Voorter P, Backes W, Barnes J, Barkhof F, Captur G, Hughes AD, Sudre C, Treibel TA. Assessment of Microvascular Disease in Heart and Brain by MRI: Application in Heart Failure with Preserved Ejection Fraction and Cerebral Small Vessel Disease. Medicina (Kaunas). 2023 Sep 4;59(9):1596. doi: 10.3390/medicina59091596. PMID: 37763715.

Assessment of the Cardiac Noncoding Transcriptome by Single-Cell RNA Sequencing Identifies FIXER, a Conserved Profibrogenic Long Noncoding RNA

Aghagolzadeh P, Plaisance I, Bernasconi R, Treibel TA, Pulido Quetglas C, Wyss T, Wigger L, Nemir M, Sarre A, Chouvardas P, Johnson R, González A, Pedrazzini T. Assessment of the Cardiac Noncoding Transcriptome by Single-Cell RNA Sequencing Identifies FIXER, a Conserved Profibrogenic Long Noncoding RNA. Circulation. 2023 Aug 29;148(9):778-797. doi: 10.1161/CIRCULATIONAHA.122.062601. Epub 2023 Jul 10. PMID: 37427428.

Arterial pulse wave modeling and analysis for vascular-age studies: a review from VascAgeNet

Alastruey J, Charlton PH, Bikia V, Paliakaite B, Hametner B, Bruno RM, Mulder MP, Vennin S, Piskin S, Khir AW, Guala A, Mayer CC, Mynard J, Hughes AD, Segers P, Westerhof BE. Arterial pulse wave modeling and analysis for vascular-age studies: a review from VascAgeNet. Am J Physiol Heart Circ Physiol. 2023 Jul 1;325(1):H1-H29. doi: 10.1152/ajpheart.00705.2022. Epub 2023 Mar 31. PMID: 37000606

Q-VAT: Quantitative Vascular Analysis Tool

Callewaert B, Gsell W, Himmelreich U, Jones EAV. Q-VAT: Quantitative Vascular Analysis Tool. Front Cardiovasc Med. 2023 Jun 2;10:1147462. doi: 10.3389/fcvm.2023.1147462. PMID: 37332588

Improving microstructural integrity, interstitial fluid, and blood microcirculation images from multi-b-value diffusion MRI using physics-informed neural networks in cerebrovascular disease

Voorter PHM, Backes WH, Gurney-Champion OJ, Wong SM, Staals J, van Oostenbrugge RJ, van der Thiel MM, Jansen JFA, Drenthen GS. Improving microstructural integrity, interstitial fluid, and blood microcirculation images from multi-b-value diffusion MRI using physics-informed neural networks in cerebrovascular disease. Magn Reson Med. 2023 Oct;90(4):1657-1671. doi: 10.1002/mrm.29753. Epub 2023 Jun 15. PMID: 37317641

Evaluation of Microvascular Rarefaction in Vascular Cognitive Impairment and Heart Failure (CRUCIAL): Study Protocol for an Observational Study.

van Dinther M, Bennett J, Thornton GD, Voorter PHM, Ezponda Casajús A, Hughes A, Captur G, Holtackers RJ; CRUCIAL Consortium Clinical Members; Staals J, Backes WH, Bastarika G, Jones EAV, González A, van Oostenbrugge RJ, Treibel TA. Evaluation of Microvascular Rarefaction in Vascular Cognitive Impairment and Heart Failure (CRUCIAL): Study Protocol for an Observational Study. Cerebrovasc Dis Extra. 2023;13(1):18-32. doi: 10.1159/000529067. Epub 2023 Jan 16. Erratum in: Cerebrovasc Dis Extra. 2023 Nov 6;13(1):1-90. PMID: 36646051

Prediction of Left Ventricular Reverse Remodeling and Outcomes by Circulating Collagen-Derived Peptides

Ravassa S, Lupón J, López B, Codina P, Domingo M, Revuelta-López E, Moreno MU, San José G, Santiago-Vacas E, Cediel G, Roncal C, Díez J, Bayés-Genís A, González A. Prediction of Left Ventricular Reverse Remodeling and Outcomes by Circulating Collagen-Derived Peptides. JACC Heart Fail. 2023 Jan;11(1):58-72. doi: 10.1016/j.jchf.2022.09.008. Epub 2022 Nov 9. PMID: 36599551. Not open access.

Revisiting skeletal myopathy and exercise training in heart failure: Emerging role of myokines

Ramírez-Vélez R, González A, García-Hermoso A, Amézqueta IL, Izquierdo M, Díez J. Revisiting skeletal myopathy and exercise training in heart failure: Emerging role of myokines. Metabolism. 2023 Jan;138:155348. doi: 10.1016/j.metabol.2022.155348. Epub 2022 Nov 21. PMID: 36410495

SARS-CoV-2 infection causes prolonged cardiomyocyte swelling and inhibition of HIF1α translocation in an animal model COVID-19

Daems M, Liesenborghs L, Boudewijns R, Simmonds SJ, Kraisin S, Van Wauwe J, Cuijpers I, Raman J, Geuens N, Buyten TV, Lox M, Verhamme P, Van Linthout S, Martinod K, Heymans S, Tschöpe C, Neyts J, Jones EAV. SARS-CoV-2 infection causes prolonged cardiomyocyte swelling and inhibition of HIF1α translocation in an animal model COVID-19. Front Cardiovasc Med. 2022 Oct 17;9:964512. doi: 10.3389/fcvm.2022.964512. PMID: 36324747.

Retinal microvascular function is associated with the cerebral microcirculation as determined by intravoxel incoherent motion MRI

van Dinther M, Voorter PHM, Schram MT, Berendschot TTJM, Houben AJHM, Webers CAB, van Oostenbrugge RJ, Backes WH, Staals J, Jansen JFA. Retinal microvascular function is associated with the cerebral microcirculation as determined by intravoxel incoherent motion MRI. J Neurol Sci. 2022 Sep 15;440:120359. doi: 10.1016/j.jns.2022.120359. Epub 2022 Jul 28. PMID: 35917773

Heart failure in chronic kidney disease: the emerging role of myocardial fibrosis

Romero-González G, González A, López B, Ravassa S, Díez J. Heart failure in chronic kidney disease: the emerging role of myocardial fibrosis. Nephrol Dial Transplant. 2022 Apr 25;37(5):817-824. doi: 10.1093/ndt/gfaa284. PMID: 33313766. Not open access.

Endotrophin, a Collagen VI Formation-Derived Peptide, in Heart Failure

Chirinos JA, Zhao L, Reese-Petersen AL, Cohen JB, Genovese F, Richards AM, Doughty RN, Díez J, González A, Querejeta R, Zamani P, Nuñez J, Wang Z, Ebert C, Kammerhoff K, Maranville J, Basso M, Qian C, Rasmussen DGK, Schafer PH, Seiffert D, Karsdal MA, Gordon DA, Ramirez-Valle F, Cappola TP Endotrophin, a Collagen VI Formation-Derived Peptide, in Heart Failure.” NEJM Evidence 2022 1(10): EVIDoa2200091

Cardiac remodelling - Part 1: From cells and tissues to circulating biomarkers. A review from the Study Group on Biomarkers of the Heart Failure Association of the European Society of Cardiology

González A, Richards AM, de Boer RA, Thum T, Arfsten H, Hülsmann M, Falcao-Pires I, Díez J, Foo RSY, Chan MY, Aimo A, Anene-Nzelu CG, Abdelhamid M, Adamopoulos S, Anker SD, Belenkov Y, Ben Gal T, Cohen-Solal A, Böhm M, Chioncel O, Delgado V, Emdin M, Jankowska EA, Gustafsson F, Hill L, Jaarsma T, Januzzi JL, Jhund PS, Lopatin Y, Lund LH, Metra M, Milicic D, Moura B, Mueller C, Mullens W, Núñez J, Piepoli MF, Rakisheva A, Ristić AD, Rossignol P, Savarese G, Tocchetti CG, Van Linthout S, Volterrani M, Seferovic P, Rosano G, Coats AJS, Bayés-Genís A. Cardiac remodelling – Part 1: From cells and tissues to circulating biomarkers. A review from the Study Group on Biomarkers of the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail. 2022 Jun;24(6):927-943. doi: 10.1002/ejhf.2493. Epub 2022 Apr 21. PMID: 35334137

Non-Invasive Evaluation of Cerebral Microvasculature Using Pre-Clinical MRI: Principles, Advantages and Limitations

Callewaert B, Jones EAV, Himmelreich U, Gsell W. Non-Invasive Evaluation of Cerebral Microvasculature Using Pre-Clinical MRI: Principles, Advantages and Limitations. Diagnostics (Basel). 2021 May 21;11(6):926. doi: 10.3390/diagnostics11060926. PMID: 34064194; PMCID: PMC8224283.

Editorial: Endothelial Dynamics in Health and Disease

Jones EAV, Graupera M, van Buul JD, Huveneers S. Editorial: Endothelial Dynamics in Health and Disease. Front Physiol. 2020 Nov 19;11:611117. doi: 10.3389/fphys.2020.611117. PMID: 33329063; PMCID: PMC7711136

Extracerebral microvascular dysfunction is related to brain MRI markers of cerebral small vessel disease: The Maastricht Study

Van Dinther M, Schram MT, Jansen JFA, Backes WH, Houben AJHM, Berendschot TTJM, Schalkwijk CG, Stehouwer CDA, van Oostenbrugge RJ, Staals J. Extracerebral microvascular dysfunction is related to brain MRI markers of cerebral small vessel disease: The Maastricht Study. Geroscience. 2022 Feb;44(1):147-157. http://doi: 10.1007/s11357-021-00493-0. Epub 2021 Nov 23. PMID: 34816376.

Assessment of microvascular rarefaction in human brain disorders using physiological magnetic resonance imaging

Van Dinther M, Voorter PH, Jansen JF, Jones EA, van Oostenbrugge RJ, Staals J, Backes WH. Assessment of microvascular rarefaction in human brain disorders using physiological magnetic resonance imaging. J Cereb Blood Flow Metab. 2022 Jan 26:271678X221076557. doi: https://10.1177/0271678X221076557 . Epub ahead of print. PMID: 35078344.

Management of cardiac fibrosis is the largest unmet medical need in heart failure

Díez J, de Boer RA. Management of cardiac fibrosis is the largest unmet medical need in heart failure. Cardiovasc Res. 2021 Jul 9:cvab228. https://doi.org/10.1093/cvr/cvab228. PMID: 34244741.

Vessel Enlargement in Development and Pathophysiology

Gifre-Renom L, Jones EAV. Vessel Enlargement in Development and Pathophysiology. Front Physiol. 2021 Feb 25;12:639645. https://doi.org/10.3389/fphys.2021.639645. PMID: 33716786.

A Comprehensive View on MRI Techniques for Imaging Blood-Brain Barrier Integrity

Elschot EP, Backes WH, Postma AA, van Oostenbrugge RJ, Staals J, Rouhl RPW, Jansen JFA. A Comprehensive View on MRI Techniques for Imaging Blood-Brain Barrier Integrity. Invest Radiol. 2021 Jan;56(1):10-19. https://doi.org/10.1097/RLI.0000000000000723. PMID: 32932377.

Time-efficient measurement of subtle blood-brain barrier leakage using a T1 mapping MRI protocol at 7 T

van den Kerkhof M, Voorter PHM, Canjels LPW, de Jong JJA, van Oostenbrugge RJ, Kroon AA, Jansen JFA, Backes WH. Time-efficient measurement of subtle blood-brain barrier leakage using a T₁ mapping MRI protocol at 7 T. Magn Reson Med. 2021 May;85(5):2761-2770. https://doi.org/10.1002/mrm.28629. PMID: 33349996.

The effect of different anaesthetics on echocardiographic evaluation of diastolic dysfunction in a heart failure with preserved ejection fraction model

Cuijpers, Ilona & Carai, Paolo & Ferreira, Pedro & Simmonds, Steven & Mulder, Paul & Miranda-Silva, Daniela & Daria, De & Pokreisz, Peter & Heymans, Stephane & Jones, Elizabeth. (2020). The effect of different anaesthetics on echocardiographic evaluation of diastolic dysfunction in a heart failure with preserved ejection fraction model. Scientific reports. https://doi.org/10.1038/s41598-020-72924-5

The Myocardium in Aortic Stenosis Revisited: More Complex Than Just Myocytes and Interstitial Diffuse Fibrosis

Camelliti P, Kriston-Vizi J, Eiros R, Thornton GD, Savvatis K, Ashworth MA, Lopez B, González A, Moon JC, Treibel TA. The Myocardium in Aortic Stenosis Revisited: More Complex Than Just Myocytes and Interstitial Diffuse Fibrosis. JACC Cardiovasc Imaging. 2020 Oct;13(10):2270-2273. doi: https://doi.org/10.1016/j.jcmg.2020.05.023. PMID: 32739378.

Fluid flow as a driver of embryonic morphogenesis

Daems M, Peacock HM, Jones EAV. Fluid flow as a driver of embryonic morphogenesis. Development. 2020 Aug 7;147(15):dev185579. https://doi.org/ 10.1242/dev.185579. PMID: 32769200.

Role of Cardiac Lymphatics in Myocardial Edema and Fibrosis: JACC Review Topic of the Week

Brakenhielm E, González A, Díez J. Role of Cardiac Lymphatics in Myocardial Edema and Fibrosis: JACC Review Topic of the Week. J Am Coll Cardiol. 2020 Aug 11;76(6):735-744. https://doi.org/10.1016/j.jacc.2020.05.076. PMID: 32762908.