Myocardial Interstitial Fibrosis in Hypertensive Heart Disease: From Mechanisms to Clinical Management. Hypertension
González A, López B, Ravassa S, San José G, Latasa I, Butler J, Díez J. Myocardial Interstitial Fibrosis in Hypertensive Heart Disease: From Mechanisms to Clinical Management. Hypertension. 2024 Feb;81(2):218-228. doi: 10.1161/HYPERTENSIONAHA.123.21708. Epub 2023 Dec 12. PMID: 38084597. (open access)
Blood–Brain Barrier Disruption and Perivascular Spaces in Small Vessel Disease and Neurodegenerative Diseases: A Review on MRI Methods and Insights
Paulien H. M. Voorter, Maud van Dinther, Willemijn J. Jansen, Alida A. Postma, Julie Staals, Jacobus F. A. Jansen, Robert J. van Oostenbrugge, Merel M. van der Thiel, Walter H. Backes; Journal of Magnetic Resonance Imaging; DOI: 10.1002/jmri.28989
Improving microstructural integrity, interstitial fluid, and blood microcirculation images from multi-b-value diffusion MRI using physics-informed neural networks in cerebrovascular disease
Paulien H. M. Voorter, Walter H. Backes, Oliver J. Gurney-Champion, Sau-May Wong, Julie Staals, Robert J. van Oostenbrugge, Merel M. van der Thiel, Jacobus F. A. Jansen, Gerhard S. Drenthen; Magnetic Resonance in Medicine; DOI: 10.1002/mrm.29753
Time‐efficient measurement of subtle blood–brain barrier leakage using a T1 mapping MRI protocol at 7 T
Marieke Kerkhof, Paulien H. M. Voorter, Lisanne P. W. Canjels, Joost J. A. Jong, Robert J. Oostenbrugge, Abraham A. Kroon, Jacobus F. A. Jansen, Walter H. Backes; Magnetic Resonance in Medicine; 85/5; DOI: 10.1002/mrm.28629
Generation of Self-Induced Myocardial Ischemia in Large-Sized Cardiac Spheroids without Alteration of Environmental Conditions Recreates Fibrotic Remodeling and Tissue Stiffening Revealed by Constriction Assays
Paz-Artigas L, González-Lana S, Polo N, Vicente P, Montero-Calle P, Martínez MA, Rábago G, Serra M, Prósper F, Mazo MM, González A, Ochoa I, Ciriza J. Generation of Self-Induced Myocardial Ischemia in Large-Sized Cardiac Spheroids without Alteration of Environmental Conditions Recreates Fibrotic Remodeling and Tissue Stiffening Revealed by Constriction Assays. ACS Biomater Sci Eng. 2024 Feb 12;10(2):987-997. doi: 10.1021/acsbiomaterials.3c01302. Epub 2024 Jan 17. PMID: 38234159.
Lower cerebral blood flow predicts cognitive decline in patients with vascular cognitive impairment. Alzheimers Dement.
van Dinther M, Hooghiemstra AM, Bron EE, Versteeg A, Leeuwis AE, Kalay T, Moonen JE, Kuipers S, Backes WH, Jansen JFA, van Osch MJP, Biessels GJ, Staals J, van Oostenbrugge RJ; Heart-Brain Connection consortium. Lower cerebral blood flow predicts cognitive decline in patients with vascular cognitive impairment. Alzheimers Dement. 2024 Jan;20(1):136-144. doi: 10.1002/alz.13408. Epub 2023 Jul 25. PMID: 37491840.
Blood-Brain Barrier Disruption and Perivascular Spaces in Small Vessel Disease and Neurodegenerative Diseases: A Review on MRI Methods and Insights
Voorter PHM, van Dinther M, Jansen WJ, Postma AA, Staals J, Jansen JFA, van Oostenbrugge RJ, van der Thiel MM, Backes WH. Blood-Brain Barrier Disruption and Perivascular Spaces in Small Vessel Disease and Neurodegenerative Diseases: A Review on MRI Methods and Insights. J Magn Reson Imaging. 2024 Feb;59(2):397-411. doi: 10.1002/jmri.28989. Epub 2023 Sep 1. PMID: 37658640.
Pericyte loss initiates microvascular dysfunction in the development of diastolic dysfunction
Simmonds SJ, Grootaert MOJ, Cuijpers I, Carai P, Geuens N, Herwig M, Baatsen P, Hamdani N, Luttun A, Heymans S, Jones EAV. Pericyte loss initiates microvascular dysfunction in the development of diastolic dysfunction. Eur Heart J Open. 2023 Dec 9;4(1):oead129. doi: 10.1093/ehjopen/oead129. PMID: 38174347.
Evaluation of Microvascular Rarefaction in Vascular Cognitive Impairment and Heart Failure (CRUCIAL): Study Protocol for an Observational Study
van Dinther M, Bennett J, Thornton GD, Voorter PHM, Ezponda Casajús A, Hughes A, Captur G, Holtackers RJ; CRUCIAL Consortium Clinical Members; Staals J, Backes WH, Bastarika G, Jones EAV, González A, van Oostenbrugge RJ, Treibel TA. Evaluation of Microvascular Rarefaction in Vascular Cognitive Impairment and Heart Failure (CRUCIAL): Study Protocol for an Observational Study. Cerebrovasc Dis Extra. 2023;13(1):18-32. doi: 10.1159/000529067. Epub 2023 Jan 16. Erratum in: Cerebrovasc Dis Extra. 2023 Nov 6;13(1):1-90. PMID: 36646051.
Effect of blood pressure-lowering agents on microvascular function in people with small vessel diseases (TREAT-SVDs): a multicentre, open-label, randomised, crossover trial
Kopczak A, Stringer MS, van den Brink H, Kerkhofs D, Blair GW, van Dinther M, Reyes CA, Garcia DJ, Onkenhout L, Wartolowska KA, Thrippleton MJ, Kampaite A, Duering M, Staals J, Lesnik-Oberstein S, Muir KW, Middeke M, Norrving B, Bousser MG, Mansmann U, Rothwell PM, Doubal FN, van Oostenbrugge R, Biessels GJ, Webb AJS, Wardlaw JM, Dichgans M; TREAT-SVDs collaborators. Effect of blood pressure-lowering agents on microvascular function in people with small vessel diseases (TREAT-SVDs): a multicentre, open-label, randomised, crossover trial. Lancet Neurol. 2023 Nov;22(11):991-1004. doi: 10.1016/S1474-4422(23)00293-4. PMID: 37863608. Not open access
Assessment of Microvascular Disease in Heart and Brain by MRI: Application in Heart Failure with Preserved Ejection Fraction and Cerebral Small Vessel Disease
Bennett J, van Dinther M, Voorter P, Backes W, Barnes J, Barkhof F, Captur G, Hughes AD, Sudre C, Treibel TA. Assessment of Microvascular Disease in Heart and Brain by MRI: Application in Heart Failure with Preserved Ejection Fraction and Cerebral Small Vessel Disease. Medicina (Kaunas). 2023 Sep 4;59(9):1596. doi: 10.3390/medicina59091596. PMID: 37763715.
Assessment of the Cardiac Noncoding Transcriptome by Single-Cell RNA Sequencing Identifies FIXER, a Conserved Profibrogenic Long Noncoding RNA
Aghagolzadeh P, Plaisance I, Bernasconi R, Treibel TA, Pulido Quetglas C, Wyss T, Wigger L, Nemir M, Sarre A, Chouvardas P, Johnson R, González A, Pedrazzini T. Assessment of the Cardiac Noncoding Transcriptome by Single-Cell RNA Sequencing Identifies FIXER, a Conserved Profibrogenic Long Noncoding RNA. Circulation. 2023 Aug 29;148(9):778-797. doi: 10.1161/CIRCULATIONAHA.122.062601. Epub 2023 Jul 10. PMID: 37427428.
Arterial pulse wave modeling and analysis for vascular-age studies: a review from VascAgeNet
Alastruey J, Charlton PH, Bikia V, Paliakaite B, Hametner B, Bruno RM, Mulder MP, Vennin S, Piskin S, Khir AW, Guala A, Mayer CC, Mynard J, Hughes AD, Segers P, Westerhof BE. Arterial pulse wave modeling and analysis for vascular-age studies: a review from VascAgeNet. Am J Physiol Heart Circ Physiol. 2023 Jul 1;325(1):H1-H29. doi: 10.1152/ajpheart.00705.2022. Epub 2023 Mar 31. PMID: 37000606
Quantitative Vascular Analysis Tool. Front Cardiovasc Med
Callewaert B, Gsell W, Himmelreich U, Jones EAV. Q-VAT: Quantitative Vascular Analysis Tool. Front Cardiovasc Med. 2023 Jun 2;10:1147462. doi: 10.3389/fcvm.2023.1147462. PMID: 37332588
Improving microstructural integrity, interstitial fluid, and blood microcirculation images from multi-b-value diffusion MRI using physics-informed neural networks in cerebrovascular disease
Voorter PHM, Backes WH, Gurney-Champion OJ, Wong SM, Staals J, van Oostenbrugge RJ, van der Thiel MM, Jansen JFA, Drenthen GS. Improving microstructural integrity, interstitial fluid, and blood microcirculation images from multi-b-value diffusion MRI using physics-informed neural networks in cerebrovascular disease. Magn Reson Med. 2023 Oct;90(4):1657-1671. doi: 10.1002/mrm.29753. Epub 2023 Jun 15. PMID: 37317641
Evaluation of Microvascular Rarefaction in Vascular Cognitive Impairment and Heart Failure (CRUCIAL): Study Protocol for an Observational Study.
van Dinther M, Bennett J, Thornton GD, Voorter PHM, Ezponda Casajús A, Hughes A, Captur G, Holtackers RJ; CRUCIAL Consortium Clinical Members; Staals J, Backes WH, Bastarika G, Jones EAV, González A, van Oostenbrugge RJ, Treibel TA. Evaluation of Microvascular Rarefaction in Vascular Cognitive Impairment and Heart Failure (CRUCIAL): Study Protocol for an Observational Study. Cerebrovasc Dis Extra. 2023;13(1):18-32. doi: 10.1159/000529067. Epub 2023 Jan 16. Erratum in: Cerebrovasc Dis Extra. 2023 Nov 6;13(1):1-90. PMID: 36646051
Prediction of Left Ventricular Reverse Remodeling and Outcomes by Circulating Collagen-Derived Peptides
Ravassa S, Lupón J, López B, Codina P, Domingo M, Revuelta-López E, Moreno MU, San José G, Santiago-Vacas E, Cediel G, Roncal C, Díez J, Bayés-Genís A, González A. Prediction of Left Ventricular Reverse Remodeling and Outcomes by Circulating Collagen-Derived Peptides. JACC Heart Fail. 2023 Jan;11(1):58-72. doi: 10.1016/j.jchf.2022.09.008. Epub 2022 Nov 9. PMID: 36599551. Not open access.
Revisiting skeletal myopathy and exercise training in heart failure: Emerging role of myokines
Ramírez-Vélez R, González A, García-Hermoso A, Amézqueta IL, Izquierdo M, Díez J. Revisiting skeletal myopathy and exercise training in heart failure: Emerging role of myokines. Metabolism. 2023 Jan;138:155348. doi: 10.1016/j.metabol.2022.155348. Epub 2022 Nov 21. PMID: 36410495
SARS-CoV-2 infection causes prolonged cardiomyocyte swelling and inhibition of HIF1α translocation in an animal model COVID-19
Daems M, Liesenborghs L, Boudewijns R, Simmonds SJ, Kraisin S, Van Wauwe J, Cuijpers I, Raman J, Geuens N, Buyten TV, Lox M, Verhamme P, Van Linthout S, Martinod K, Heymans S, Tschöpe C, Neyts J, Jones EAV. SARS-CoV-2 infection causes prolonged cardiomyocyte swelling and inhibition of HIF1α translocation in an animal model COVID-19. Front Cardiovasc Med. 2022 Oct 17;9:964512. doi: 10.3389/fcvm.2022.964512. PMID: 36324747.
Retinal microvascular function is associated with the cerebral microcirculation as determined by intravoxel incoherent motion MRI
van Dinther M, Voorter PHM, Schram MT, Berendschot TTJM, Houben AJHM, Webers CAB, van Oostenbrugge RJ, Backes WH, Staals J, Jansen JFA. Retinal microvascular function is associated with the cerebral microcirculation as determined by intravoxel incoherent motion MRI. J Neurol Sci. 2022 Sep 15;440:120359. doi: 10.1016/j.jns.2022.120359. Epub 2022 Jul 28. PMID: 35917773
Heart failure in chronic kidney disease: the emerging role of myocardial fibrosis
Romero-González G, González A, López B, Ravassa S, Díez J. Heart failure in chronic kidney disease: the emerging role of myocardial fibrosis. Nephrol Dial Transplant. 2022 Apr 25;37(5):817-824. doi: 10.1093/ndt/gfaa284. PMID: 33313766. Not open access.
Endotrophin, a Collagen VI Formation-Derived Peptide, in Heart Failure
Chirinos JA, Zhao L, Reese-Petersen AL, Cohen JB, Genovese F, Richards AM, Doughty RN, Díez J, González A, Querejeta R, Zamani P, Nuñez J, Wang Z, Ebert C, Kammerhoff K, Maranville J, Basso M, Qian C, Rasmussen DGK, Schafer PH, Seiffert D, Karsdal MA, Gordon DA, Ramirez-Valle F, Cappola TP Endotrophin, a Collagen VI Formation-Derived Peptide, in Heart Failure.” NEJM Evidence 2022 1(10): EVIDoa2200091
Cardiac remodelling - Part 1: From cells and tissues to circulating biomarkers. A review from the Study Group on Biomarkers of the Heart Failure Association of the European Society of Cardiology
González A, Richards AM, de Boer RA, Thum T, Arfsten H, Hülsmann M, Falcao-Pires I, Díez J, Foo RSY, Chan MY, Aimo A, Anene-Nzelu CG, Abdelhamid M, Adamopoulos S, Anker SD, Belenkov Y, Ben Gal T, Cohen-Solal A, Böhm M, Chioncel O, Delgado V, Emdin M, Jankowska EA, Gustafsson F, Hill L, Jaarsma T, Januzzi JL, Jhund PS, Lopatin Y, Lund LH, Metra M, Milicic D, Moura B, Mueller C, Mullens W, Núñez J, Piepoli MF, Rakisheva A, Ristić AD, Rossignol P, Savarese G, Tocchetti CG, Van Linthout S, Volterrani M, Seferovic P, Rosano G, Coats AJS, Bayés-Genís A. Cardiac remodelling – Part 1: From cells and tissues to circulating biomarkers. A review from the Study Group on Biomarkers of the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail. 2022 Jun;24(6):927-943. doi: 10.1002/ejhf.2493. Epub 2022 Apr 21. PMID: 35334137
A Comprehensive View on MRI Techniques for Imaging Blood-Brain Barrier Integrity
Elschot EP, Backes WH, Postma AA, van Oostenbrugge RJ, Staals J, Rouhl RPW, Jansen JFA. A Comprehensive View on MRI Techniques for Imaging Blood-Brain Barrier Integrity. Invest Radiol. 2021 Jan;56(1):10-19. doi: 10.1097/RLI.0000000000000723. PMID: 32932377
Time-efficient measurement of subtle blood-brain barrier leakage using a T1 mapping MRI protocol at 7 T
van den Kerkhof M, Voorter PHM, Canjels LPW, de Jong JJA, van Oostenbrugge RJ, Kroon AA, Jansen JFA, Backes WH. Time-efficient measurement of subtle blood-brain barrier leakage using a T1 mapping MRI protocol at 7 T. Magn Reson Med. 2021 May;85(5):2761-2770. doi: 10.1002/mrm.28629. Epub 2020 Dec 8. PMID: 33349996; PMCID: PMC7898690
Non-Invasive Evaluation of Cerebral Microvasculature Using Pre-Clinical MRI: Principles, Advantages and Limitations
Callewaert B, Jones EAV, Himmelreich U, Gsell W. Non-Invasive Evaluation of Cerebral Microvasculature Using Pre-Clinical MRI: Principles, Advantages and Limitations. Diagnostics (Basel). 2021 May 21;11(6):926. doi: 10.3390/diagnostics11060926. PMID: 34064194; PMCID: PMC8224283.
Editorial: Endothelial Dynamics in Health and Disease
Jones EAV, Graupera M, van Buul JD, Huveneers S. Editorial: Endothelial Dynamics in Health and Disease. Front Physiol. 2020 Nov 19;11:611117. doi: 10.3389/fphys.2020.611117. PMID: 33329063; PMCID: PMC7711136
Extracerebral microvascular dysfunction is related to brain MRI markers of cerebral small vessel disease: The Maastricht Study
Van Dinther M, Schram MT, Jansen JFA, Backes WH, Houben AJHM, Berendschot TTJM, Schalkwijk CG, Stehouwer CDA, van Oostenbrugge RJ, Staals J. Extracerebral microvascular dysfunction is related to brain MRI markers of cerebral small vessel disease: The Maastricht Study. Geroscience. 2022 Feb;44(1):147-157. http://doi: 10.1007/s11357-021-00493-0. Epub 2021 Nov 23. PMID: 34816376.
Assessment of microvascular rarefaction in human brain disorders using physiological magnetic resonance imaging
Van Dinther M, Voorter PH, Jansen JF, Jones EA, van Oostenbrugge RJ, Staals J, Backes WH. Assessment of microvascular rarefaction in human brain disorders using physiological magnetic resonance imaging. J Cereb Blood Flow Metab. 2022 Jan 26:271678X221076557. doi: https://10.1177/0271678X221076557 . Epub ahead of print. PMID: 35078344.
Management of cardiac fibrosis is the largest unmet medical need in heart failure
Díez J, de Boer RA. Management of cardiac fibrosis is the largest unmet medical need in heart failure. Cardiovasc Res. 2021 Jul 9:cvab228. https://doi.org/10.1093/cvr/cvab228. PMID: 34244741.
Vessel Enlargement in Development and Pathophysiology
Gifre-Renom L, Jones EAV. Vessel Enlargement in Development and Pathophysiology. Front Physiol. 2021 Feb 25;12:639645. https://doi.org/10.3389/fphys.2021.639645. PMID: 33716786.
A Comprehensive View on MRI Techniques for Imaging Blood-Brain Barrier Integrity
Elschot EP, Backes WH, Postma AA, van Oostenbrugge RJ, Staals J, Rouhl RPW, Jansen JFA. A Comprehensive View on MRI Techniques for Imaging Blood-Brain Barrier Integrity. Invest Radiol. 2021 Jan;56(1):10-19. https://doi.org/10.1097/RLI.0000000000000723. PMID: 32932377.
Heart failure in chronic kidney disease: the emerging role of myocardial fibrosis
Romero-González G, González A, López B, Ravassa S, Díez J. Heart failure in chronic kidney disease: the emerging role of myocardial fibrosis. Nephrol Dial Transplant. 2020 Dec 13:gfaa284. doi: https://doi.org/10.1093/ndt/gfaa284. PMID: 33313766.
Time-efficient measurement of subtle blood-brain barrier leakage using a T1 mapping MRI protocol at 7 T
van den Kerkhof M, Voorter PHM, Canjels LPW, de Jong JJA, van Oostenbrugge RJ, Kroon AA, Jansen JFA, Backes WH. Time-efficient measurement of subtle blood-brain barrier leakage using a T1 mapping MRI protocol at 7 T. Magn Reson Med. 2021 May;85(5):2761-2770. https://doi.org/10.1002/mrm.28629. PMID: 33349996.
The effect of different anaesthetics on echocardiographic evaluation of diastolic dysfunction in a heart failure with preserved ejection fraction model
Cuijpers, Ilona & Carai, Paolo & Ferreira, Pedro & Simmonds, Steven & Mulder, Paul & Miranda-Silva, Daniela & Daria, De & Pokreisz, Peter & Heymans, Stephane & Jones, Elizabeth. (2020). The effect of different anaesthetics on echocardiographic evaluation of diastolic dysfunction in a heart failure with preserved ejection fraction model. Scientific reports. https://doi.org/10.1038/s41598-020-72924-5
The Myocardium in Aortic Stenosis Revisited: More Complex Than Just Myocytes and Interstitial Diffuse Fibrosis
Camelliti P, Kriston-Vizi J, Eiros R, Thornton GD, Savvatis K, Ashworth MA, Lopez B, González A, Moon JC, Treibel TA. The Myocardium in Aortic Stenosis Revisited: More Complex Than Just Myocytes and Interstitial Diffuse Fibrosis. JACC Cardiovasc Imaging. 2020 Oct;13(10):2270-2273. doi: https://doi.org/10.1016/j.jcmg.2020.05.023. PMID: 32739378.
Fluid flow as a driver of embryonic morphogenesis
Daems M, Peacock HM, Jones EAV. Fluid flow as a driver of embryonic morphogenesis. Development. 2020 Aug 7;147(15):dev185579. https://doi.org/ 10.1242/dev.185579. PMID: 32769200.
Role of Cardiac Lymphatics in Myocardial Edema and Fibrosis: JACC Review Topic of the Week
Brakenhielm E, González A, Díez J. Role of Cardiac Lymphatics in Myocardial Edema and Fibrosis: JACC Review Topic of the Week. J Am Coll Cardiol. 2020 Aug 11;76(6):735-744. https://doi.org/10.1016/j.jacc.2020.05.076. PMID: 32762908.
This project has received funding from the SESAR Joint Undertaking under the European Union’s Horizon 2020 research and innovation programme under grant agreement No 848109.